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Legal blindness

MedGen UID:
78763
•Concept ID:
C0271215
•
Disease or Syndrome
Synonyms: Blindness, Legal; Legal Blindness
SNOMED CT: Legal blindness (65956007)

Professional guidelines

PubMed

Piloting a forced-choice task to elicit treatment preferences in geographic atrophy.
Enoch J, Ghulakhszian A, Sekhon M, Crabb DP, Taylor DJ, Dinah C
BMC Res Notes 2023 Sep 30;16(1):244. doi: 10.1186/s13104-023-06531-8. PMID: 37777762Free PMC Article
Intermediate uveitis associated with MS: Diagnosis, clinical features, pathogenic mechanisms, and recommendations for management.
Abraham A, Nicholson L, Dick A, Rice C, Atan D
Neurol Neuroimmunol Neuroinflamm 2021 Jan;8(1) Epub 2020 Oct 30 doi: 10.1212/NXI.0000000000000909. PMID: 33127747Free PMC Article
Treatment of age-related macular degeneration.
Bylsma GW, Guymer RH
Clin Exp Optom 2005 Sep;88(5):322-34. doi: 10.1111/j.1444-0938.2005.tb06716.x. PMID: 16255691

Recent clinical studies

Etiology

Aging, Cellular Senescence, and Glaucoma.
Zhang Y, Huang S, Xie B, Zhong Y
Aging Dis 2024 Apr 1;15(2):546-564. doi: 10.14336/AD.2023.0630-1. PMID: 37725658Free PMC Article
Age-related macular degeneration.
Fleckenstein M, Keenan TDL, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, Wong WT, Chew EY
Nat Rev Dis Primers 2021 May 6;7(1):31. doi: 10.1038/s41572-021-00265-2. PMID: 33958600
Autoimmunity in uveitis.
Ten Berge JC, Schreurs MWJ, van Daele PLA, Rothova A
Acta Ophthalmol 2018 Aug;96(5):481-485. Epub 2018 Jan 25 doi: 10.1111/aos.13652. PMID: 29369534
Cone rod dystrophies.
Hamel CP
Orphanet J Rare Dis 2007 Feb 1;2:7. doi: 10.1186/1750-1172-2-7. PMID: 17270046Free PMC Article
Open-angle glaucoma.
Distelhorst JS, Hughes GM
Am Fam Physician 2003 May 1;67(9):1937-44. PMID: 12751655

Diagnosis

Age-related macular degeneration.
Fleckenstein M, Keenan TDL, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, Wong WT, Chew EY
Nat Rev Dis Primers 2021 May 6;7(1):31. doi: 10.1038/s41572-021-00265-2. PMID: 33958600
Optical Coherence Tomography-Angiography in Geographic Atrophy.
Müller PL, Pfau M, Schmitz-Valckenberg S, Fleckenstein M, Holz FG
Ophthalmologica 2021;244(1):42-50. Epub 2020 Aug 7 doi: 10.1159/000510727. PMID: 32772015
Macular Edema in Childhood Uveitis.
Garweg JG
Klin Monbl Augenheilkd 2018 Apr;235(4):373-376. Epub 2018 Feb 16 doi: 10.1055/s-0043-123650. PMID: 29452454
Dominant optic atrophy.
Lenaers G, Hamel C, Delettre C, Amati-Bonneau P, Procaccio V, Bonneau D, Reynier P, Milea D
Orphanet J Rare Dis 2012 Jul 9;7:46. doi: 10.1186/1750-1172-7-46. PMID: 22776096Free PMC Article
Open-angle glaucoma.
Distelhorst JS, Hughes GM
Am Fam Physician 2003 May 1;67(9):1937-44. PMID: 12751655

Therapy

The Benefits of Flavonoids in Diabetic Retinopathy.
Matos AL, Bruno DF, Ambrósio AF, Santos PF
Nutrients 2020 Oct 16;12(10) doi: 10.3390/nu12103169. PMID: 33081260Free PMC Article
Macular Edema in Childhood Uveitis.
Garweg JG
Klin Monbl Augenheilkd 2018 Apr;235(4):373-376. Epub 2018 Feb 16 doi: 10.1055/s-0043-123650. PMID: 29452454
Neuropeptides and diabetic retinopathy.
Gábriel R
Br J Clin Pharmacol 2013 May;75(5):1189-201. doi: 10.1111/bcp.12003. PMID: 23043302Free PMC Article
Age-related macular degeneration (AMD): pathogenesis and therapy.
Nowak JZ
Pharmacol Rep 2006 May-Jun;58(3):353-63. PMID: 16845209
Open-angle glaucoma.
Distelhorst JS, Hughes GM
Am Fam Physician 2003 May 1;67(9):1937-44. PMID: 12751655

Prognosis

Optical Coherence Tomography-Angiography in Geographic Atrophy.
Müller PL, Pfau M, Schmitz-Valckenberg S, Fleckenstein M, Holz FG
Ophthalmologica 2021;244(1):42-50. Epub 2020 Aug 7 doi: 10.1159/000510727. PMID: 32772015
Macular Edema in Childhood Uveitis.
Garweg JG
Klin Monbl Augenheilkd 2018 Apr;235(4):373-376. Epub 2018 Feb 16 doi: 10.1055/s-0043-123650. PMID: 29452454
Autoimmunity in uveitis.
Ten Berge JC, Schreurs MWJ, van Daele PLA, Rothova A
Acta Ophthalmol 2018 Aug;96(5):481-485. Epub 2018 Jan 25 doi: 10.1111/aos.13652. PMID: 29369534
Dominant optic atrophy.
Lenaers G, Hamel C, Delettre C, Amati-Bonneau P, Procaccio V, Bonneau D, Reynier P, Milea D
Orphanet J Rare Dis 2012 Jul 9;7:46. doi: 10.1186/1750-1172-7-46. PMID: 22776096Free PMC Article
Cone rod dystrophies.
Hamel CP
Orphanet J Rare Dis 2007 Feb 1;2:7. doi: 10.1186/1750-1172-2-7. PMID: 17270046Free PMC Article

Clinical prediction guides

Do Nutrients and Nutraceuticals Play a Role in Diabetic Retinopathy? A Systematic Review.
Milluzzo A, Barchitta M, Maugeri A, Magnano San Lio R, Favara G, Mazzone MG, Sciacca L, Agodi A
Nutrients 2022 Oct 21;14(20) doi: 10.3390/nu14204430. PMID: 36297113Free PMC Article
Blindness and visual impairment in Central Europe.
Glatz M, Riedl R, Glatz W, Schneider M, Wedrich A, Bolz M, Strauss RW
PLoS One 2022;17(1):e0261897. Epub 2022 Jan 13 doi: 10.1371/journal.pone.0261897. PMID: 35025896Free PMC Article
Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies.
Curcio CA
Invest Ophthalmol Vis Sci 2018 Mar 20;59(4):AMD160-AMD181. doi: 10.1167/iovs.18-24882. PMID: 30357336Free PMC Article
Autoimmunity in uveitis.
Ten Berge JC, Schreurs MWJ, van Daele PLA, Rothova A
Acta Ophthalmol 2018 Aug;96(5):481-485. Epub 2018 Jan 25 doi: 10.1111/aos.13652. PMID: 29369534
Childhood-onset Leber hereditary optic neuropathy.
Majander A, Bowman R, Poulton J, Antcliff RJ, Reddy MA, Michaelides M, Webster AR, Chinnery PF, Votruba M, Moore AT, Yu-Wai-Man P
Br J Ophthalmol 2017 Nov;101(11):1505-1509. Epub 2017 Mar 17 doi: 10.1136/bjophthalmol-2016-310072. PMID: 28314831

Recent systematic reviews

Do Nutrients and Nutraceuticals Play a Role in Diabetic Retinopathy? A Systematic Review.
Milluzzo A, Barchitta M, Maugeri A, Magnano San Lio R, Favara G, Mazzone MG, Sciacca L, Agodi A
Nutrients 2022 Oct 21;14(20) doi: 10.3390/nu14204430. PMID: 36297113Free PMC Article
Visual Deficits and Dysfunctions Associated with Traumatic Brain Injury: A Systematic Review and Meta-analysis.
Merezhinskaya N, Mallia RK, Park D, Bryden DW, Mathur K, Barker FM 2nd
Optom Vis Sci 2019 Aug;96(8):542-555. doi: 10.1097/OPX.0000000000001407. PMID: 31343512
Corticosteroid implants for chronic non-infectious uveitis.
Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J
Cochrane Database Syst Rev 2016 Feb 12;2(2):CD010469. doi: 10.1002/14651858.CD010469.pub2. PMID: 26866343Free PMC Article
Systematic review of anti-tumor necrosis factor-alpha therapy for treatment of immune-mediated uveitis.
Cordero-Coma M, Yilmaz T, Onal S
Ocul Immunol Inflamm 2013;21(1):19-27. doi: 10.3109/09273948.2012.723107. PMID: 23323577
Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: a systematic review and economic evaluation.
Colquitt JL, Jones J, Tan SC, Takeda A, Clegg AJ, Price A
Health Technol Assess 2008 May;12(16):iii-iv, ix-201. doi: 10.3310/hta12160. PMID: 18462575

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